[HTML][HTML] … , and organometry of early peripheral immunoendocrine impairment in adult 3xTg-AD mice and their long-lasting ontogenic modulation by neonatal handling

R Baeta-Corral, M De la Fuente… - Behavioural Brain …, 2023 - Elsevier
… that neonatal handling may exert a potential modification of … the first time this sex dimorphism
in the 3xTg-AD mice. Moreover, … Cognitive and emotional alterations in young Alzheimer's

[HTML][HTML] Sexual dimorphism in the 3xTg-AD mouse model and its impact on pre-clinical research

JL Dennison, NR Ricciardi, I Lohse… - … Alzheimer's disease, 2021 - content.iospress.com
… experience worse pathology and faster cognitive decline. Pre-clinical … modifications such as
methylation and acetylation [31]. These … and no analysis was performed on AβPP processing

Social nesting, animal welfare, and disease monitoring

L Giménez-Llort, V Torres-Lista - Animals, 2021 - mdpi.com
… , cognitive, and behavioral effects of neonatal handling in … of male and female 3xTg-AD
mice in social nesting under … activity, but not the modification of vertical exploratory activity, …

[HTML][HTML] Dopaminergic dysfunction in the 3xTg-AD mice model of Alzheimer's disease

Y Gloria, K Ceyzériat, S Tsartsalis, P Millet… - Scientific reports, 2021 - nature.com
… could have consequences in behavior and cognitive function… effects (locomotion and locomotor
response to stimulation of D 2 … that 3xTg-AD mice show dopaminergic system alterations

[HTML][HTML] Anxiety and Alzheimer's disease pathogenesis: focus on 5-HT and CRF systems in 3xTg-AD and TgF344-AD animal models

NC Reyna, BJ Clark, DA Hamilton… - Frontiers in Aging …, 2023 - ncbi.nlm.nih.gov
… Further, the TgF344-AD rat model yielded more consistent cognitive and … of this system could
promote psychological well-being (eg, … modulation by neonatal handling. Behav. Brain Res. …

[HTML][HTML] Differential effects of chronic immunosuppression on behavioral, epigenetic, and Alzheimer's disease-associated markers in 3xTg-AD mice

M Kapadia, MF Mian, D Ma, CP Hutton, A Azam… - Alzheimer's Research & …, 2021 - Springer
… in 3xTg-AD mice, behavioral deficits similar to mild cognitive … in the context of the altered
3xTg-AD phenotype, the current … is highly responsive to environmental stimuli [123], including …

Sex-dependent end-of-life mental and vascular scenarios for compensatory mechanisms in mice with normal and ad-neurodegenerative aging

A Muntsant, F Jiménez-Altayó, L Puertas-Umbert… - Biomedicines, 2021 - mdpi.com
… -like and cognitive phenotypes (worse in 3xTg-AD females), and … , vascular alterations of
female 3xTg-AD mice were found … the HPA axis exhibited sexual dimorphism, with higher levels …

Gut microbiota alterations and cognitive impairment are sexually dissociated in a transgenic mice model of Alzheimer's disease

D Cuervo-Zanatta, J Garcia-Mena… - … Alzheimer's disease, 2021 - content.iospress.com
Cognitive abilities showed a sex dimorphism in young and old … on tests of mental rotation
of spatial stimuli [12, 13] compared … alterations early than the previously used 3xTgAD mice. …

[HTML][HTML] Life Experience Matters: Enrichment and Stress Can Influence the Likelihood of Developing Alzheimer's Disease via Gut Microbiome

SE Torraville, CM Flynn, TL Kendall, Q Yuan - Biomedicines, 2023 - mdpi.com
… used repeated cognitive testing as intellectual or cognitive enrichment in their 3xTG-AD mouse
… As shown in Table 3, studies in mice induced gut microbiota alterations between stressed …

Sex-and Neuropsychiatric-Dependent Circadian Alterations in Daily Voluntary Physical Activity Engagement and Patterns in Aged 3xTg-AD Mice

D Alveal-Mellado, L Castillo-Mariqueo… - International journal of …, 2022 - mdpi.com
… of the disease [2], including affective disorders (anxiety and … association of worsening
NPS-like symptoms in the 3xTg-ADeffect of PA starting at the late stages of AD, once cognitive